The scene was along the 1400 block of Strawberry Drive in Ceres.
Ceres Fire and other agencies responded to the fire around 4 a.m. and found that one home was fully engulfed. Flames had also spread to a second home and a third was threatened.
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Firefighters say the residents were able to get out safely, but they needed to be treated for smoke inhalation. A few other homes in the neighborhood were also evacuated for a time due to the incident.
The fire went to two-alarms. No other injuries were reported.
Firefighters say they were able to find two dogs and two cats, but other pets remain missing.
Exactly what caused the fire is under investigation.